{"id":26160,"date":"2021-05-04T16:40:33","date_gmt":"2021-05-04T13:40:33","guid":{"rendered":"https:\/\/ramonfoundation.org.il\/?p=26160"},"modified":"2021-05-12T12:31:16","modified_gmt":"2021-05-12T09:31:16","slug":"%d7%90%d7%95%d7%a4%d7%98%d7%99%d7%a7%d7%94-%d7%a0%d7%99%d7%a1%d7%95%d7%99-%d7%94%d7%98%d7%9c%d7%a1%d7%a7%d7%95%d7%a4-%d7%94%d7%a0%d7%95%d7%96%d7%9c%d7%99-flute-2-2-2-2-2-2-2-4-2-4-2-2-3-2-2-2-2-2-2-52","status":"publish","type":"post","link":"https:\/\/ramonfoundation.org.il\/?p=26160","title":{"rendered":"BBB in space"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"26160\" class=\"elementor elementor-26160\" data-elementor-settings=\"[]\">\n\t\t\t\t\t\t<div class=\"elementor-inner\">\n\t\t\t\t\t\t\t<div class=\"elementor-section-wrap\">\n\t\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-b1ee109 elementor-section-full_width elementor-section-height-default elementor-section-height-default\" data-id=\"b1ee109\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-4fec058\" data-id=\"4fec058\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-ac1ee2a elementor-widget elementor-widget-text-editor\" data-id=\"ac1ee2a\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><a style=\"color: white;\" href=\"https:\/\/ramonfoundation.org.il\/?p=25487\">HE<\/a> | <a style=\"color: white;\" href=\"https:\/\/ramonfoundation.org.il\/?p=29484\">\u0639\u0631\u0628\u064a\u0647<\/a><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-top-column elementor-element elementor-element-175431e\" data-id=\"175431e\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-b61adc1 elementor-nav-menu__align-center elementor-nav-menu__text-align-center elementor-nav-menu--dropdown-tablet elementor-nav-menu--toggle elementor-nav-menu--burger elementor-widget elementor-widget-nav-menu\" data-id=\"b61adc1\" data-element_type=\"widget\" data-settings=\"{&quot;submenu_icon&quot;:{&quot;value&quot;:&quot;&lt;i 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Team<\/a><\/li>\n<\/ul><\/nav>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-02028cb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"02028cb\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-8f02008\" data-id=\"8f02008\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-64ff1b7 elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"64ff1b7\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"334\" height=\"335\" src=\"https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/M2-1.png\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/M2-1.png 334w, https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/M2-1-300x300.png 300w, https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/M2-1-150x150.png 150w\" sizes=\"(max-width: 334px) 100vw, 334px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e997340 elementor-hidden-desktop elementor-widget elementor-widget-image\" data-id=\"e997340\" data-element_type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"241\" height=\"240\" src=\"https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/8.png\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/8.png 241w, https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/8-150x150.png 150w\" sizes=\"(max-width: 241px) 100vw, 241px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb08035 elementor-widget__width-inherit elementor-absolute elementor-widget elementor-widget-image\" data-id=\"eb08035\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"334\" height=\"335\" src=\"https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/M2-1.png\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/M2-1.png 334w, https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/M2-1-300x300.png 300w, https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/M2-1-150x150.png 150w\" sizes=\"(max-width: 334px) 100vw, 334px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-357b04a elementor-widget elementor-widget-heading\" data-id=\"357b04a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">BBB in space<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3e9c10a elementor-widget elementor-widget-heading\" data-id=\"3e9c10a\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\"> Sheba Medical Center<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-88607aa elementor-widget elementor-widget-heading\" data-id=\"88607aa\" data-element_type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\">Dr. Itzik Cooper<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b084cd6 elementor-hidden-phone elementor-absolute elementor-widget elementor-widget-image\" data-id=\"b084cd6\" data-element_type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-image\">\n\t\t\t\t\t\t\t\t\t\t\t\t<img width=\"241\" height=\"240\" src=\"https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/8.png\" class=\"attachment-large size-large\" alt=\"\" loading=\"lazy\" srcset=\"https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/8.png 241w, https:\/\/ramonfoundation.org.il\/wp-content\/uploads\/2021\/05\/8-150x150.png 150w\" sizes=\"(max-width: 241px) 100vw, 241px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-f026220 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"f026220\" data-element_type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4457351\" data-id=\"4457351\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8f0d0c7 elementor-widget elementor-widget-text-editor\" data-id=\"8f0d0c7\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><span data-sheets-value=\"{&quot;1&quot;:2,&quot;2&quot;:&quot;Study the effects of microgravity on Alzheimer\u2019s pathology using BBB-on-Chip in space&quot;}\" data-sheets-userformat=\"{&quot;2&quot;:5059,&quot;3&quot;:{&quot;1&quot;:0},&quot;4&quot;:{&quot;1&quot;:2,&quot;2&quot;:65280},&quot;9&quot;:1,&quot;10&quot;:1,&quot;11&quot;:4,&quot;12&quot;:0,&quot;15&quot;:&quot;arial, sans, sans-serif&quot;}\">Study the effects of microgravity on Alzheimer\u2019s pathology using BBB-on-Chip in space<\/span><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8fb914b elementor-widget elementor-widget-text-editor\" data-id=\"8fb914b\" data-element_type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-clearfix\">\n\t\t\t\t<p><span data-sheets-value=\"{&quot;1&quot;:2,&quot;2&quot;:&quot;Dysfunction of blood-brain barrier (BBB) which is composed of brain capillaries, is an early biomarker of Alzheimer\u2019s disease leading to brain chemical dyshomeostasis and cognitive impairment. Maintaining BBB integrity is thus an attractive therapeutic target. Microgravity conditions affects vasculatures in various ways, however its influence on brain vascular function and potential BBB-targeted therapeutics in the context of Alzheimer\u2019s are not known. Moreover, amyloid \u03b2- the pathological hallmark of Alzheimer\u2019s - has been shown to aggregate slower in space which may lead to reduced neurotoxicity. Therefore, we will mimic the Alzheimer\u2019s neurovasculature pathology using BBB-on-Chip, and study its functionality in space.&quot;}\" data-sheets-userformat=\"{&quot;2&quot;:5059,&quot;3&quot;:{&quot;1&quot;:0},&quot;4&quot;:{&quot;1&quot;:2,&quot;2&quot;:65280},&quot;9&quot;:0,&quot;10&quot;:1,&quot;11&quot;:4,&quot;12&quot;:0,&quot;15&quot;:&quot;arial, sans, sans-serif&quot;}\">Dysfunction of blood-brain barrier (BBB) which is composed of brain capillaries, is an early biomarker of Alzheimer\u2019s disease leading to brain chemical dyshomeostasis and cognitive impairment. Maintaining BBB integrity is thus an attractive therapeutic target. Microgravity conditions affects vasculatures in various ways, however its influence on brain vascular function and potential BBB-targeted therapeutics in the context of Alzheimer\u2019s are not known. Moreover, amyloid \u03b2- the pathological hallmark of Alzheimer\u2019s &#8211; has been shown to aggregate slower in space which may lead to reduced neurotoxicity. Therefore, we will mimic the Alzheimer\u2019s neurovasculature pathology using BBB-on-Chip, and study its functionality in space.<\/span><\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b54d069 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"b54d069\" data-element_type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t<a href=\"mailto:itzik.cooper@sheba.health.gov.il\" class=\"elementor-button-link elementor-button elementor-size-sm\" role=\"button\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-text\">contact mail<\/span>\n\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-5c479d6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"5c479d6\" data-element_type=\"section\" data-settings=\"{&quot;background_background&quot;:&quot;classic&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t\t\t<div class=\"elementor-row\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c16f6b2\" data-id=\"c16f6b2\" data-element_type=\"column\">\n\t\t\t<div class=\"elementor-column-wrap elementor-element-populated\">\n\t\t\t\t\t\t\t<div class=\"elementor-widget-wrap\">\n\t\t\t\t\t\t<div class=\"elementor-element 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